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after taking quinin expectorated blood。 The petechiae were profusely spread over the entire body； and they disappeared after the suspension of the drug。 Dauboeuf； Garraway； Hemming； Skinner； and Cobner mention roseola and scarlatiniform erythema after minute doses of quinin。 In nearly all these cases the accompanying symptoms were different。 Heusinger speaks of a lady who； after taking 1/2 grain of quinin； experienced headache； nausea； intense burning； and edema； together with nodular erythema on the eyelids； cheeks； and portion of the forehead。 At another time 1 1/2 grains of the drug gave rise to herpetic vesicles on the cheeks； followed by branny desquamation on elimination of the drug。 In other patients intense itching is experienced after the ingestion of quinin。 Peters cites an instance of a woman of sixty…five who； after taking one grain of quinin； invariably exhibited after an hour a temperature of from 104 degrees to 105 degrees F。； accelerated pulse； rigors； slight delirium； thirst； and all the appearances of ill…defined fever； which would pass off in from twelve to twenty…four hours。 Peters witnessed this idiosyncrasy several times and believed it to be permanent。 The most unpleasant of the untoward symptoms of quinin exhibition are the disturbances of the organs of special sense。 Photophobia； and even transient amblyopia； have been observed to follow small doses。 In the examination of cases of the untoward effects of quinin upon the eye； Knapp of New York found the power of sight diminished in various degrees； and rarely amaurosis and immobility of the pupils。 According to Lewin； the perceptions of color and light are always diminished； and although the disorder may last for some time the prognosis is favorable。 The varieties of the disturbances of the functions of the ear range from tinnitus aurium to congestion causing complete deafness。 The gastro…intestinal and genito…urinary tracts are especially disposed to untoward action by quinin。 There is a case recorded in which； after the slightest dose of quinin； tingling and burning at the meatus urinarius were experienced。 According to Lewin； there is mentioned in the case reported by Gauchet a symptom quite unique in the literature of quinin； viz。； hemoptysis。 Simon de Ronchard first noted the occurrence of several cases of hemoptysis following the administration of doses of eight grains daily。 In the persons thus attacked the lungs and heart were healthy。 Hemoptysis promptly ceased with the suspension of the drug。 When it was renewed； blood again appeared in the sputa。 Taussig mentions a curious mistake； in which an ounce of quinin sulphate was administered to a patient at one dose； the only symptoms noticed were a stuporous condition and complete deafness。 No antidote was given； and the patient perfectly recovered in a week。 In malarious countries； and particularly in the malarial fevers of the late war； enormous quantities of quinin were frequently given。 In fact； at the present day in some parts of the South quinin is constantly kept on the table as a prophylactic constituent of the diet。
Skinner noticed the occurrence of a scarlatiniform eruption in a woman after the dose of 1/165 grain of strychnin； which； however； disappeared with the discontinuance of the drug。 There was a man in London in 1865 who died in twenty minute's after the ingestion of 1/2 grain of strychnin。 Wood speaks of a case in which the administration of 1/100 grain killed a child three and one…half months old。 Gray speaks of a man who took 22 grains and was not seen for about an hour。 He had vomited some of it immediately after taking the dose； and was successfully treated with chloral hydrate。 A curious case is mentioned in which three mustard plasters； one on the throat； one on the back of the neck； and another on the left shoulder of a woman； produced symptoms similar to strychnin poisoning。 They remained in position for about thirty minutes； and about thirty hours afterward a painful stinging sensation commenced in the back of the neck； followed by violent twitching of the muscles of the face； arms； and legs； which continued in regular succession through the whole of the night； but after twelve hours yielded to hot fomentations of poppy…heads applied to the back of the neck。 It could not be ascertained whether any medicine containing strychnin had been taken； but surely； from the symptoms； such must have been the case。
Tobacco。O'Neill a gives the history of a farmer's wife； aged forty； who wounded her leg against a sewing…machine； and by lay advice applied a handful of chopped wet tobacco to it； from which procedure； strange to say； serious nicotin…poisoning ensued。 The pupils were dilated； there were dimness of vision； confusion of thought； and extreme prostration。 The pulse was scarcely apparent； the skin was white and wet with clammy perspiration。 Happily； strychnin was given in time to effect recovery； and without early medical assistance she would undoubtedly have succumbed。 There are several similar cases on record。
Although not immediately related to the subject of idiosyncrasy； the following case may be mentioned here： Ramadge speaks of a young Frenchman； suffering from an obstinate case of gonorrhea； who was said to have been completely cured by living in a newly painted house in which he inhaled the odors or vapors of turpentine。
White speaks of a case of exanthematous eruption similar to that of ivy…poison in mother and child； which was apparently caused by playing with and burning the toy called 〃Pharaoh's serpent egg。〃
The idiosyncrasies noticed in some persons during coitus are quite interesting。 The Ephemerides mentions a person in whom coitus habitually caused vomiting； and another in whom excessive sexual indulgence provoked singultus。 Sometimes exaggerated tremors or convulsions； particularly at the moment of orgasm； are noticed。 Females especially are subject to this phenomenon； and it is seen sometimes in birds。
Winn reports the case of a man who； when prompted to indulge in sexual intercourse； was immediately prior to the act seized with a fit of sneezing。 Even the thought of sexual pleasure with a female was sufficient to provoke this peculiar idiosyncrasy。
Sullivan mentions a bride of four weeks； who called at the doctor's office； saying that in coitus her partner had no difficulty until the point of culmination or orgasm； when he was seized with complete numbness and lost all pleasurable sensation in the penis。 The numbness was followed by a sensation of pain； which was intensified on the slightest motion； and which was at times so excruciating as to forbid separation for upward of an hour； or until the penis had become flaccid。 The woman asked for advice for her unfortunate husband's relief； and the case was reported as a means of obtaining suggestions from the physicians over the country。 In response； one theory was advanced that this man had been in the habit of masturbating and had a stricture of the membranous portion of the urethra； associated with an ulcer of the prostate involving the ejaculatory ducts； or an inflammatory condition of all the tissues compressed by the ejaculatory muscles。
Hendrichsen quotes a case in which a spasmodic c