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l portions of other chapters are devoted to showing that De Quincey was wrong in some of his statements； but notwithstanding his criticism of De Quincey； Mr。 Cobbe seems to have experienced the same adventures in his dreams； showing； after all； that De Quincey knew the effects of opium even if he seemed to idealize it。 According to Mr。 Cobbe； there are in the United States upward of two millions of victims of enslaving drugs entirely exclusive of alcohol。 Cobbe mentions several instances in which De Quincey's dose of 320 grains of opium daily has been surpassed。 One man； a resident of Southern Illinois； consumed 1072 grains a day； another in the same State contented himself with 1685 grains daily； and still another is given whose daily consumption amounted to 2345 grains per day。 In all cases of laudanum…takers it is probable that analysis of the commercial laudanum taken would show the amount of opium to be greatly below that of the official proportion； and little faith can be put in the records of large amounts of opium taken when the deduction has been made from the laudanum used。 Dealers soon begin to know opium victims； and find them ready dupes for adulteration。 According to Lewin； Samter mentions a case of morphin…habit which was continued for three years； during which； in a period of about three； hundred and twenty…three days； upward of 2 1/2 ounces of morphin was taken daily。 According to the same authority； Eder reports still larger doses。 In the case observed by him the patient took laudanum for six years in increasing doses up to one ounce per day； for eighteen months； pure opium； commencing with 15 grains and increasing to 2 1/4 drams daily； and for eighteen months morphin； in commencing quantities of six grains； which were later increased to 40 grains a day。 When deprived of their accustomed dose of morphin the sufferings which these patients experience are terrific； and they pursue all sorts of deceptions to enable them to get their enslaving drug。 Patients have been known to conceal tubes in their mouths； and even swallow them； and the authors know of a fatal instance in which a tube of hypodermic tablets of the drug was found concealed in the rectum。
The administration of such an inert substance as the infusion of orange…peel has been sufficient to invariably produce nervous excitement in a patient afflicted with carcinoma。
Sonnenschein refers to a case of an infant of five weeks who died from the effects of one phosphorous match head containing only 1/100 grain of phosphorus。 There are certain people who by reason of a special susceptibility cannot tolerate phosphorus； and the exhibition of it causes in them nausea； oppression； and a feeling of pain in the epigastric region； tormina and tenesmus； accompanied with diarrhea； and in rare cases jaundice； sometimes lasting several months。 In such persons 1/30 grain is capable of causing the foregoing symptoms。 In 1882 a man was admitted to Guy's Hospital； London； after he had taken half of a sixpenny pot of phosphorous paste in whiskey； and was subsequently discharged completely recovered。
A peculiar feature of phosphorus…poisoning is necrosis of the jaw。 This affection was first noticed in 1838； soon after the introduction of the manufacture of phosphorous matches。 In late years； owing to the introduction of precautions in their manufacture； the disease has become much less common。 The tipping of the match sticks is accomplished by dipping their ends in a warm solution of a composition of phosphorus； chlorate of potassium； with particles of ground flint to assist friction； some coloring agent； and Irish glue。 From the contents of the dipping…pans fumes constantly arise into the faces of the workmen and dippers； and in cutting the sticks and packing the matches the hands are constantly in contact with phosphorus。 The region chiefly affected in this poisoning is the jaw…bone； but the inflammation may spread to the adjoining bones and involve the vomer； the zygoma； the body of the spheroid bone； and the basilar process of the occipital bone。 It is supposed that conditions in which the periosteum is exposed are favorable to the progress of the disease； and； according to Hirt； workmen with diseased teeth are affected three times as readily as those with healthy teeth； and are therefore carefully excluded from some of the factories in America。
Prentiss of Washington； D。C。； in 1881 reported a remarkable case of pilocarpin idiosyncrasy in a blonde of twenty…five。 He was consulted by the patient for constipation。 Later on symptoms of cystitis developed； and an ultimate diagnosis of pyelitis of the right kidney was made。 Uremic symptoms were avoided by the constant use of pilocarpin。 Between December 16； 1880； and February 22； 1881； the patient had 22 sweats from pilocarpin。 The action usually lasted from two to six hours； and quite a large dose was at length necessary。 The idiosyncrasy noted was found in the hair； which at first was quite light； afterward chestnut…brown； and May 1； 1881； almost pure black。 The growth of the hair became more vigorous and thicker than formerly； and as its color darkened it became coarser in proportion。 In March； 1889； Prentiss saw his patient； and at that time her hair was dark brown； having returned to that color from black。 Prentiss also reported the following case a as adding another to the evidence that jaborandi will produce the effect mentioned under favorable circumstances： Mrs。 L。； aged seventy…two years； was suffering from Bright's disease （contracted kidney）。 Her hair and eyebrows had been snow…white for twenty years。 She suffered greatly from itching of the skin； due to the uremia of the kidney…disease； the skin was harsh and dry。 For this symptom fluid extract of jaborandi was prescribed with the effect of relieving the itching。 It was taken in doses of 20 or 30 drops several times a day； from October； 1886； to February； 1888。 During the fall of 1887 it was noticed by the nurse that the eyebrows were growing darker； and that the hair of the head was darker in patches。 These patches and the eyebrows continued to become darker； until at the time of her death they were quite black； the black tufts on the head presenting a very curious appearance among the silver…white hairs surrounding them。
Quinin being such a universally used drug； numerous instances of idiosyncrasy and intolerance have been recorded。 Chevalier mentions that through contact of the drug workmen in the manufacture of quinin are liable to an affection of the skin which manifests itself in a vesicular； papular； or pustular eruption on different parts of the body。 Vepan mentions a lady who took 1 1/2 grains and afterward 2 1/2 grains of quinin for neuralgia； and two days afterward her body was covered with purpuric spots； which disappeared in the course of nine days but reappeared after the administration of the drug was resumed。 Lewin says that in this case the severity of the eruption was in accordance with the size of the dose； and during its existence there was bleeding at the gums； he adds that Gouchet also noticed an eruption of this kind in a lady who after taking quinin expectorated blood。 The petechiae were profusely spread over the entire body； an