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。 A year and a half previously he had taken medicine for his pains； but its nature could not be discovered。 He had had syphilis。
Galtier mentions congenital and bronze spots of the skin。 A man born in Switzerland the latter part of the last century； calling himself Joseph Galart； attracted the attention of the curious by exhibiting himself under the name of the 〃Living Angel。〃 He presented the following appearance： The skin of the whole posterior part of the trunk； from the nape of the neck to the loins； was of a bronze color。 This color extended over the shoulders and the sides of the neck； and this part was covered with hairs of great fineness and growing very thick； the skin of the rest of the body was of the usual whiteness。 Those parts were the darkest which were the most covered with hair； on the back there was a space of an inch in diameter； which had preserved its whiteness； and where the hairs were fewer in number； darker at their bases； and surrounded by a very small black circle； the hair was thinner at the sides of the neck； there were a great many individual hairs surrounded by circles of coloring matter； but there were also many which presented nothing of this colored areola。 In some places the general dark color of the skin blended with the areola surrounding the roots of the hair； so that one uniform black surface resulted。 In many places the dark color changed into black。 The irides were brown。 The man was of very unstable character； extremely undecided in all his undertakings； and had a lively but silly expression of countenance。 A distinct smell； as of mice； with a mixture of a garlicky odor； was emitted from those parts where the excessive secretion of the coloring matter took place。 In those places the heat was also greater than natural。 Rayer recites the case of a young man whom he saw； whose eyelids and adjacent parts of the cheeks were of a bluish tint； similar to that which is produced on the skin by the explosion of gunpowder。
Billard has published an extraordinary case of blue discoloration of the skin in a young laundress of sixteen。 Her neck； face； and upper part of the chest showed a beautiful blue tint； principally spreading over the forehead； the alae； and the mouth。 When these parts were rubbed with a white towel the blue parts of the skin were detached on the towel； coloring it； and leaving the skin white。 The girl's lips were red； the pulse was regular and natural； and her strength and appetite like that of a person in health。 The only morbid symptom was a dry cough； but without mucous rattle or any deficiency of the sound of the chest or alteration of the natural beat of the heart。 The catamenia had never failed。 She had been engaged as a laundress for the past two years。 From the time she began this occupation she perceived a blueness around her eyes； which disappeared however on going into the air。 The phenomenon reappeared more particularly when irons were heated by a bright charcoal fire； or when she worked in a hot and confined place。 The blueness spread； and her breast and abdomen became shaded with an azure blue； which appeared deeper or paler as the circulation was accelerated or retarded。 When the patient's face should have blushed； the face became blue instead of red。 The changes exhibited were like the sudden transition of shades presented by the chameleon。 The posterior part of the trunk； the axillae； the sclerotic coats of the eyes； the nails； and the skin of the head remained in their natural state and preserved their natural color。 The linen of the patient was stained blue。 Chemical analysis seemed to throw no light on this case； and the patient improved on alkaline treatment。 She vomited blood； which contained sufficient of the blue matter to stain the sides of the vessel。 She also stated that in hemorrhage from the nose she had seen blue drops among the drops of blood。 One cannot but suspect indigo as a factor in the causation of this anomalous coloration。
Artificial discolorations of the skin are generally produced by tattooing； by silver nitrate； mercury； bismuth； or some other metallic salt。
Melasma has been designated as an accidental and temporary blackish discoloration of the skin。 There are several varieties： that called Addison's disease； that due to uterine disease； etc。 In this affection the skin assumes a dark and even black hue。
Leukoderma is a pathologic process； the result of which is a deficiency in the normal pigmentation of the skin； and possibly its appendages。 Its synonyms are leukopathia； vitiligo； achroma； leukasmus； and chloasma album。 In India the disease is called sufaid…korh； meaning white leprosy。 It has numerous colloquial appellations； such as chumba or phoolyree （Hindoo）； buras （Urdu）； cabbore （Singalese）； kuttam （Taneil）； dhabul （Bengal）。 It differs from albinism in being an acquired deficiency of pigment； not universal and not affecting the eye。 Albinism is congenital； and the hair and eyes are affected as well as the skin。
The disease is of universal distribution； but is naturally more noticeable in the dark…skinned races。 It is much more common in this country among the negroes than is generally supposed。
The 〃leopard…boy of Africa；〃 so extensively advertised by dime museums over the country； was a well…defined case of leukoderma in a young mulatto； a fitting parallel for the case of ichthyosis styled the 〃alligator…boy。〃
Figure 293 represents a family of three children； all the subjects of leukoderma。 Leukoderma is more common among females。 It is rarely seen in children； being particularly a disease of middle age。 Bissell reports a case in an Indian ninety years of age； subsequent to an attack of rheumatism thirty years previous。 It is of varying duration； nearly every case giving a different length of time。 It may be associated with most any disease； and is directly attributable to none。 In a number of cases collected rheumatism has been a marked feature。 It has been noticed following typhoid fever and pregnancy。
In white persons there are spots or blotches of pale； lustreless appearance either irregular or symmetric； scattered over the body。 In the negro and other dark…skinned races a mottled appearance is seen。 If the process goes to completion； the whole surface changes to white。 The hair； though rarely affected； may present a mottled appearance。 There seems to be no constitutional disturbances； no radical change in the skin； no painin fact； no disturbance worthy of note。 The eye is not affected； but in a negro the sclerotic generally appears muddy。
It appears first in small spots； either on the lips； nose； eyelids； soles； palms； or forehead； and increases peripherallythe several spots fusing together。 The skin is peculiarly thin and easily irritated。 Exposure to the sun readily blisters it； and after the slightest abrasion it bleeds freely。 Several cases have been reported in which the specific gravity of the urine was extremely high； due to an excess of urea。 Wood calls attention to the wave…like course of leukoderma； receding on one side； increasing on the other。 The fading is gradual； and the margins may be abrupt or diffuse。 The mucous membranes are rosy。 The functions of the swell…glands are unimpaired。